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Distribution of the a2, a3, and a5 nicotinic acetylcholine receptor subunits in the chick brain BJMBR
Torrão,A.S.; Lindstrom,J.M.; Britto,L.R.G..
Nicotinic acetylcholine receptors (nAChRs) are ionotropic receptors comprised of <FONT FACE="Symbol">a</font> and ß subunits. These receptors are widely distributed in the central nervous system, and previous studies have revealed specific patterns of localization for some nAChR subunits in the vertebrate brain. In the present study we used immunohistochemical methods and monoclonal antibodies to localize the <FONT FACE="Symbol">a</font>2, <FONT FACE="Symbol">a</font>3, and <FONT FACE="Symbol">a</font>5 nAChR subunits in the chick mesencephalon and diencephalon. We observed a differential distribution of these three subunits in the chick brain, and showed that the somata and neuropil of many central...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cholinergic system; Neurotransmitters; Receptors; Receptor subunits.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000011
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Frequent occurrence of nicotinic acetylcholine receptors in GABAergic neurons of the chick visual system BJMBR
Torrão,A.S.; Britto,L.R.G..
Double-labeling immunohistochemical methods were used to investigate the occurrence of the alpha8 and alpha5 nicotinic receptor subunits in presumptive GABAergic neurons of the chick nervous system. Nicotinic receptor immunoreactivity was often found in cells exhibiting GABA-like immunoreactivity, especially in the visual system. The alpha8 subunit appeared to be present in presumptive GABAergic cells of the ventral lateral geniculate nucleus, nucleus of the basal optic root of the accessory optic system, and the optic tectum, among several other structures. The alpha5 subunit was also found in GABA-positive neurons, as observed in the lentiform nucleus of the mesencephalon and other pretectal nuclei. The numbers of alpha8- and alpha5-positive neurons that...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Acetylcholine; GABA; Neurotransmitters; Nicotinic receptors; Visual system.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000013
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Unconventional neurotransmitters, neurodegeneration and neuroprotection BJMBR
Leonelli,M.; Torrão,A.S.; Britto,L.R.G..
Neurotransmitters are also involved in functions other than conventional signal transfer between nerve cells, such as development, plasticity, neurodegeneration, and neuroprotection. For example, there is a considerable amount of data indicating developmental roles for the glutamatergic, cholinergic, dopaminergic, GABA-ergic, and ATP/adenosine systems. In this review, we discuss the existing literature on these "new" functions of neurotransmitters in relation to some unconventional neurotransmitters, such as the endocannabinoids and nitric oxide. Data indicating both transcriptional and post-transcriptional modulation of endocannabinoid and nitrinergic systems after neural lesions are discussed in relation to the non-conventional roles of these...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Endocannabinoids; Cannabinoid receptors; Vanilloid receptors; Nitric oxide.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100011
Registros recuperados: 3
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